Rufy4 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol-3-phosphate binding activity. Involved in several processes, including cellular response to interleukin-4; multivesicular body-lysosome fusion; and positive regulation of bone resorption. Predicted to be located in cytoplasmic vesicle. Predicted to be active in autophagosome. Is expressed in heart; liver; lung; and metanephros. Orthologous to human RUFY4 (RUN and FYVE domain containing 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rufy4 |
| Official Name | RUN and FYVE domain containing 4 [Source:MGI Symbol;Acc:MGI:3588214] |
| Ensembl ID | ENSMUSG00000061815 |
| Bio databases IDs | |
| Aliases | RUN and FYVE domain containing 4 |
| Synonyms | F930048N03Rik, RGD1560678, RUN and FYVE domain containing 4, ZFYVE31 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rufy4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE domain like superfamily
- FYVE zinc finger
- TPR/MLP1/MLP2-like protein
- cytoskeletal protein binding
- domain involved in Ras-like GTPase signaling
- Ezrin/radixin/moesin, alpha-helical domain
- Protein present in Fab1, YOTB, Vac1, and EEA1
- PHD finger superfamily
- protein binding
- RUN domain
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- autophagic vacuoles
- endolysosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rufy4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- positive regulation of macroautophagy
- cellular response to interleukin-4
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle
- autophagic vacuole
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- phosphatidylinositol-3-phosphate binding