Cdkn2d Gene Summary [Mouse]
Enables protein kinase binding activity. Acts upstream of or within negative regulation of cell cycle G1/S phase transition and sensory perception of sound. Part of cyclin D2-CDK4 complex. Is expressed in several structures, including central nervous system; hemolymphoid system gland; liver; musculature; and trigeminal nerve. Orthologous to human CDKN2D (cyclin dependent kinase inhibitor 2D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdkn2d |
| Official Name | cyclin dependent kinase inhibitor 2D [Source:MGI Symbol;Acc:MGI:105387] |
| Ensembl ID | ENSMUSG00000096472 |
| Bio databases IDs | |
| Aliases | cyclin dependent kinase inhibitor 2D |
| Synonyms | cyclin dependent kinase inhibitor 2D, INK4D, p19, p19-INK4D |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdkn2d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cyclin-dependent protein kinase inhibitor activity
- transcription regulator
- Ankyrin repeats (many copies)
- protein kinase binding
- Ankyrin repeats (3 copies)
- protein binding
- Ankyrin repeat
- ankyrin repeats
Pathways
Biological processes and signaling networks where the Cdkn2d gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- osteosarcomagenesis
- cancer
- rheumatoid arthritis
- tumorigenesis
- osteosarcoma
- tumor
- hyperplasia
- progressive hearing impairment
role in cell
- activation in
- expression in
- apoptosis
- proliferation
- growth
- differentiation
- cell death
- G1 phase
- autophagy in
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdkn2d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to vitamin D
- negative regulation of cell proliferation
- response to UV
- DNA synthesis involved in DNA repair
- negative regulation of phosphorylation
- regulation of cyclin-dependent protein kinase activity
- sensory perception of sound
- response to retinoic acid
- negative regulation of cell growth
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- autophagic cell death
- regulation of G1/S transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- cyclin D2-CDK4 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- cyclin-dependent protein kinase inhibitor activity