Trappc2l Gene Summary [Mouse]

Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be part of TRAPP complex. Predicted to be active in cytoplasm and nucleus. Is expressed in small intestine. Orthologous to human TRAPPC2L (trafficking protein particle complex subunit 2L). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Processed Transcript
Official Symbol
Trappc2l
Official Name
trafficking protein particle complex 2-like [Source:MGI Symbol;Acc:MGI:1916295]
Ensembl ID
ENSMUSG00000015013
Bio databases IDs NCBI: 59005 Ensembl: ENSMUSG00000015013
Aliases trafficking protein particle complex 2-like
Synonyms 1810017G16Rik, HSPC176, LOC51693, PERRB, RGD1304906, Tca17, trafficking protein particle complex 2L, trafficking protein particle complex subunit 2L
Species
Mouse, Mus musculus
OrthologiesHuman

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trappc2l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Sedlin, N-terminal conserved region
  • protein binding
  • Longin-like domains

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • early-onset progressive encephalopathy with episodic rhabdomyolysis
  • colon carcinoma
  • colon epithelial cancer
  • rheumatoid arthritis
regulated by
  • T lymphocytes
  • CTNNB1
  • ROR2
  • hematopoietic progenitor cells
role in cell
  • DT-061 sensitivity

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • intracellular membrane-bounded organelle
  • cytosol

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Trappc2l gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • vesicle coating
  • ER to Golgi vesicle-mediated transport
  • COPII vesicle coating

Cellular Component

Where in the cell the gene product is active
  • TRAPP complex
  • nucleus
  • perinuclear region of cytoplasm
  • cytoplasm
  • intracellular membrane-bounded organelle
  • cytosol
  • endoplasmic reticulum

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

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