Sorcs3 Gene Summary [Mouse]
Involved in postsynaptic modulation of chemical synaptic transmission. Acts upstream of or within learning; memory; and regulation of long-term synaptic depression. Located in postsynaptic density. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including brain; cochlea; genitourinary system; retina; and trigeminal ganglion. Orthologous to human SORCS3 (sortilin related VPS10 domain containing receptor 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sorcs3 |
| Official Name | sortilin-related VPS10 domain containing receptor 3 [Source:MGI Symbol;Acc:MGI:1913923] |
| Ensembl ID | ENSMUSG00000063434 |
| Bio databases IDs | |
| Aliases | sortilin-related VPS10 domain containing receptor 3 |
| Synonyms | 6330404A12RIK, SORCS, sortilin-related VPS10 domain containing receptor 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sorcs3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sortilin, neurotensin receptor 3, C-terminal
- PKD domain
- Sortilin, neurotensin receptor 3,
- VPS10 domain
- Cadherin repeat-like domain
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiovascular disorder
- hypertension
- Alzheimer disease
- pain
- depressive disorder
- major depression
- neuroticism
- attention deficit hyperactivity disorder
- diabetic nephropathy
- pervasive developmental disorder
role in cell
- expression in
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- cellular membrane
- Plasma Membrane
- synaptic membrane
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sorcs3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- regulation of long term synaptic depression
- learning
- memory
Cellular Component
Where in the cell the gene product is active
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- neuropeptide receptor activity