Srrm4 Gene Summary [Mouse]
Enables mRNA binding activity. Involved in several processes, including mRNA processing; nervous system development; and regulation of alternative mRNA splicing, via spliceosome. Acts upstream of or within sensory perception of sound. Located in nucleus. Is expressed in brain; cochlear ganglion; and inner ear. Orthologous to human SRRM4 (serine/arginine repetitive matrix 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Srrm4 |
| Official Name | serine/arginine repetitive matrix 4 [Source:MGI Symbol;Acc:MGI:1916205] |
| Ensembl ID | ENSMUSG00000063919 |
| Bio databases IDs | |
| Aliases | serine/arginine repetitive matrix 4 |
| Synonyms | 1500001A10RIK, B230202K19Rik, bv, KIAA1853, LOC144747, mKIAA1853, MU-MB-2.76, nSR100, RGD1560213, serine/arginine repetitive matrix 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Srrm4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA binding
- Serine/arginine repetitive matrix protein C-terminus
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- coronary artery disease
- psoriasis
- hearing loss
- stroke
- ischemic stroke
regulates
role in cell
- expression in
- cell viability
- outgrowth
- differentiation
- production in
- development
- alternative splicing by
- guidance
- regulation in
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Srrm4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- RNA splicing
- regulation of alternative nuclear mRNA splicing, via spliceosome
- regulation of RNA splicing
- cell differentiation
- nervous system development
- neuron maturation
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- mRNA binding