Pepd Gene Summary [Mouse]
Enables peptidase activity. Predicted to be involved in negative regulation of programmed cell death and proteolysis. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in prolidase deficiency. Orthologous to human PEPD (peptidase D). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pepd |
| Official Name | peptidase D [Source:MGI Symbol;Acc:MGI:97542] |
| Ensembl ID | ENSMUSG00000063931 |
| Bio databases IDs | |
| Aliases | peptidase D |
| Synonyms | dal, LOC103690062, PEP4, peptidase D, PROLIDASE |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pepd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Metallopeptidase family M24
- Aminopeptidase P, N-terminal domain
- dipeptidase
- peptidase
- metallocarboxypeptidase
- protein binding
- X-Pro dipeptidase
- APP_MetAP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- EGFR
- collagen
- amino acids
disease
- metabolic syndrome X
- deficiency of prolidase
- non-insulin-dependent diabetes mellitus
- venous thromboembolism
- diabetes mellitus
- gestational diabetes mellitus
- schizophrenia
- male pattern hair loss
- megaconial type congenital muscular dystrophy
phenotypes
- abnormal behavior
- abnormal bone structure
- abnormal cornea morphology
- abnormal joint morphology
- abnormal optic disk morphology
- abnormal retina morphology
- decreased Ly6C-positive NK T cell number
- decreased bone mineral content
- decreased bone mineral density
- decreased circulating iron level
- decreased immature B cell number
- decreased total body fat amount
- decreased transitional stage T1 B cell number
- decreased vertical activity
- hyperactivity
- hypoactivity
- increased CD4-positive alpha beta T cell number
- increased anxiety-related response
- increased circulating aspartate transaminase level
- increased effector memory CD8-positive alpha-beta T cell number
- increased effector memory T-helper cell number
- increased lean body mass
- increased leukocyte cell number
- increased memory CD4-positive CD25-positive alpha-beta regulatory T cell number
- increased memory-marker CD4-negative NK T cell number
- increased memory-marker NK cell number
- increased thigmotaxis
- increased total body fat amount
- short tibia
- small stomach
- abnormal adipose tissue amount
- abnormal agouti pigmentation
- abnormal anxiety-related response
- abnormal aorta collagen fibril morphology
- abnormal bone mineral density
- abnormal bone mineralization
- abnormal cardiac muscle tissue morphology
- abnormal fetal cardiomyocyte morphology
- abnormal heart morphology
- abnormal heart septum morphology
- abnormal leukocyte cell number
- abnormal locomotor activation
- abnormal myocardial fiber morphology
- abnormal seminiferous tubule morphology
- abnormal testis interstitial tissue morphology
- abnormal testis morphology
- abnormal urine homeostasis
- atrioventricular septal defect
- brain vacuoles
- darkened coat color
- decreased body size
- decreased circulating testosterone level
- decreased collagen level
- decreased oocyte number
- embryonic growth retardation
- increased atrioventricular cushion size
- irregular coat pigmentation
- myocardium hypertrophy
- postnatal lethality incomplete penetrance
- prenatal lethality incomplete penetrance
- preweaning lethality
- small testis
- thick interventricular septum
- thick ventricular wall
- ventricular septal defect
role in cell
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pepd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- cellular amino acid metabolic process
- collagen catabolic process
- negative regulation of programmed cell death
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- metallocarboxypeptidase activity
- metalloaminopeptidase activity
- manganese ion binding
- peptidase activity