Usp36 Gene Summary [Mouse]
Predicted to enable K48-linked deubiquitinase activity; cysteine-type deubiquitinase activity; and histone H2B deubiquitinase activity. Involved in several processes, including nucleolus organization; protein stabilization; and regulation of rRNA processing. Predicted to be located in cytoplasm; nuclear speck; and nucleolus. Predicted to be active in cytosol and nucleus. Orthologous to human USP36 (ubiquitin specific peptidase 36). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Usp36 |
| Official Name | ubiquitin specific peptidase 36 [Source:MGI Symbol;Acc:MGI:1919594] |
| Ensembl ID | ENSMUSG00000033909 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 36 |
| Synonyms | 2700002L06RIK, DUB1, mKIAA1453, ubiquitin specific peptidase 36 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Usp36 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- ubiquitin-specific protease
- Ubiquitin carboxyl-terminal hydrolase
- protein binding
- enzyme
- Peptidase_C19
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the Usp36 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- neoplasia
- gastric cancer
- cardiovascular disorder
- coronary artery disease
- metabolic syndrome X
- breast cancer
- insulin resistance
- organismal death
- metastasis
role in cell
- activation in
- expression in
- apoptosis
- cell viability
- migration
- ubiquitination in
- proliferation
- molecular cleavage in
- accumulation in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nucleoli
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Usp36 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- chromatin remodeling
- regulation of protein stability
- nucleolus organization
- proteolysis
- negative regulation of macroautophagy
- regulation of apoptotic process
- regulation of rRNA processing
- chromatin organization
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- RNA binding
- protein binding
- transferase activity