Fbln2 Gene Summary [Mouse]
Enables extracellular matrix binding activity. Acts upstream of or within positive regulation of cell-substrate adhesion. Located in collagen-containing extracellular matrix. Is expressed in several structures, including central nervous system; embryo mesenchyme; intraembryonic coelom; sensory organ; and skeleton. Orthologous to human FBLN2 (fibulin 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbln2 |
| Official Name | fibulin 2 [Source:MGI Symbol;Acc:MGI:95488] |
| Ensembl ID | ENSMUSG00000064080 |
| Bio databases IDs | |
| Aliases | fibulin 2 |
| Synonyms | 5730577E14RIK, FIBL-2, fibulin 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbln2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular matrix constituent conferring elasticity
- Complement Clr-like EGF-like
- extracellular matrix binding
- calcium ion binding
- extracellular matrix structural constituent
- protein binding
- ANATO
- Coagulation Factor Xa inhibitory site
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cirrhosis
- COVID-19
- neoplasia
- pulmonary hypertensive arterial disease
- asthma
- age-related macular degeneration
- colorectal cancer
- experimentally induced cirrhosis
- epithelial cancer
- androgenic alopecia
role in cell
- expression in
- growth
- proliferation
- migration
- invasion by
- angiogenesis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Nucleus
- cytoplasmic matrix
- photoreceptor outer segments
- microfibrils
- extracellular matrix
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbln2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell-substrate adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- extracellular matrix binding
- protein binding
- calcium ion binding
- extracellular matrix constituent conferring elasticity
- extracellular matrix structural constituent