Clec4d Gene Summary [Mouse]
Enables immunoglobulin receptor binding activity. Involved in antifungal innate immune response; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of myeloid dendritic cell activation. Acts upstream of or within several processes, including Fc-gamma receptor signaling pathway; T cell differentiation involved in immune response; and defense response to other organism. Located in plasma membrane. Is expressed in several structures, including heart; immune system; intestine; liver; and lung. Orthologous to human CLEC4D (C-type lectin domain family 4 member D). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Clec4d |
| Official Name | C-type lectin domain family 4, member d [Source:MGI Symbol;Acc:MGI:1298389] |
| Ensembl ID | ENSMUSG00000030144 |
| Bio databases IDs | |
| Aliases | C-type lectin domain family 4, member d |
| Synonyms | CD368, CLEC-6, CLECSF8, C-type lectin domain family 4 member D, C-type lectin domain family 4, member D, Dectin-3, MCL, MPCL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clec4d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Lectin C-type domain
- protein binding
- receptor binding
- mannose binding
Pathways
Biological processes and signaling networks where the Clec4d gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- experimental autoimmune encephalomyelitis
- rheumatoid arthritis
- sepsis
- septic shock
- delayed hypersensitive reaction
- infection by bacteria
role in cell
- proliferation
- production in
- number
- activation
- activation in
- respiratory burst in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- cellular membrane
- secretory granule membrane
- tertiary granule membrane
- specific granule membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Clec4d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of myeloid dendritic cell activation
- T cell differentiation involved in immune response
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- Fc-gamma receptor signaling pathway
- adaptive immune response
- defense response to bacterium
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
- tertiary granule membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- mannose binding
- protein binding
- metal ion binding
- carbohydrate binding
- immunoglobulin receptor binding