Mcm8 Gene Summary [Mouse]
Predicted to enable several functions, including chromatin binding activity; mismatch repair complex binding activity; and single-stranded DNA binding activity. Predicted to contribute to single-stranded DNA helicase activity. Involved in double-strand break repair via homologous recombination; female gamete generation; and male gamete generation. Part of MCM8-MCM9 complex. Is expressed in several structures, including alimentary system; central nervous system; sensory organ; submandibular gland primordium; and vibrissa. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 10. Orthologous to human MCM8 (minichromosome maintenance 8 homologous recombination repair factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mcm8 |
| Official Name | minichromosome maintenance 8 homologous recombination repair factor [Source:MGI Symbol;Acc:MGI:1913884] |
| Ensembl ID | ENSMUSG00000027353 |
| Bio databases IDs | |
| Aliases | minichromosome maintenance 8 homologous recombination repair factor |
| Synonyms | 5730432L01RIK, C20orf154, dJ967N21.5, MENOQ3, minichromosome maintenance 8 homologous recombination repair factor, POF10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mcm8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme binding
- MCM P-loop domain
- chromatin binding
- enzyme
- protein binding
- MCM AAA-lid domain
- MCM helicase family
- minichromosome maintenance proteins
- AAA domain (dynein-related subfamily)
- MCM OB domain
- binding protein
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the Mcm8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- premature ovarian failure type 10
- breast carcinoma
- estrogen receptor positive breast cancer
- uterine leiomyoma
- leiomyomatosis
- azoospermia
- estrogen receptor-negative breast cancer
- menorrhagia
- preeclampsia
role in cell
- growth
- apoptosis
- proliferation
- number
- DNA damage response
- damage
- generation
- abnormal morphology
- damage in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- soluble fraction
- chromatin fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mcm8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male gamete generation
- female gamete generation
- mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication
- protein localization to chromatin
- DNA replication
- DNA duplex unwinding
- double-strand break repair via homologous recombination
- protein stabilization
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome
- MCM complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- MutSalpha complex binding
- MutSbeta complex binding
- ATP binding
- MutLbeta complex binding
- protein binding
- chromatin binding
- single-stranded DNA-dependent ATP-dependent DNA helicase activity
- enzyme binding
- single-stranded DNA binding