Far2 Gene Summary [Mouse]
Enables alcohol-forming very long-chain fatty acyl-CoA reductase activity. Predicted to be involved in long-chain fatty-acyl-CoA metabolic process. Predicted to act upstream of or within wax biosynthetic process. Located in peroxisome. Is expressed in alveolar sulcus; anterior naris; brain; ovary; and skin. Used to study alopecia and dry eye syndrome. Orthologous to human FAR2 (fatty acyl-CoA reductase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Far2 |
| Official Name | fatty acyl CoA reductase 2 [Source:MGI Symbol;Acc:MGI:2687035] |
| Ensembl ID | ENSMUSG00000030303 |
| Bio databases IDs | |
| Aliases | fatty acyl CoA reductase 2 |
| Synonyms | A230046P18, AW048109, fatty acyl-CoA reductase 2, HEL-S-81, MLSTD1, RGD1565966, SDR10E2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Far2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- Male sterility protein
- oxidoreductase
- enzyme
- aldehyde or oxo group:NAD or NADP oxidoreductase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisome membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Far2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-chain fatty-acyl-CoA metabolic process
- wax biosynthetic process
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- peroxisome
Molecular Function
What the gene product does at the molecular level
- oxidoreductase activity
- fatty-acyl-CoA reductase (alcohol-forming) activity