Myo1h Gene Summary [Mouse]

Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization; actin filament-based movement; and endocytosis. Predicted to be located in cluster of actin-based cell projections. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; microvillus; and plasma membrane. Is expressed in several structures, including alimentary system; gonad; nervous system; neural retina; and respiratory system. Human ortholog(s) of this gene implicated in congenital central hypoventilation syndrome. Orthologous to human MYO1H (myosin IH). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Myo1h
Official Name
myosin 1H [Source:MGI Symbol;Acc:MGI:1914674]
Ensembl ID
ENSMUSG00000066952
Bio databases IDs NCBI: 231646 Ensembl: ENSMUSG00000066952
Aliases myosin 1H
Synonyms 4631401O15Rik, AABR07036550.1, CCHS2, LOC108352465, myosin 1H, myosin IH
Species
Mouse, Mus musculus
OrthologiesHuman

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myo1h often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • IQ (isoleucine-glutamine) motif containing G and D (IQCG and IQCD)
  • Myosin and Kinesin motor domain
  • Unconventional myosin tail, actin- and lipid-binding
  • Myosin
  • Myosin head (motor domain)

Pathways

Biological processes and signaling networks where the Myo1h gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • major depression
  • schizophrenia
  • insomnia
  • neuroticism
  • congenital central hypoventilation syndrome 2 and autonomic dysfunction
  • headache
  • neurotic disorder
regulated by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Unknown

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Myo1h gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • actin filament organization
  • actin filament-based movement
  • endocytosis

Cellular Component

Where in the cell the gene product is active
  • myosin complex
  • cytoplasm
  • microvillus
  • actin cytoskeleton
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • actin filament binding
  • ATP binding
  • microfilament motor activity

Gene-Specific Assays for Results You Can Trust

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