MYO1H Gene Summary [Human]
Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization and vesicle transport along actin filament. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; microvillus; and vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MYO1H |
| Official Name | myosin IH [Source:HGNC Symbol;Acc:HGNC:13879] |
| Ensembl ID | ENSG00000174527 |
| Bio databases IDs | |
| Aliases | myosin IH, Unconventional myosin-Ih |
| Synonyms | 4631401O15Rik, AABR07036550.1, CCHS2, LOC108352465, myosin 1H, myosin IH |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MYO1H often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IQ (isoleucine-glutamine) motif containing G and D (IQCG and IQCD)
- Myosin and Kinesin motor domain
- Unconventional myosin tail, actin- and lipid-binding
- Myosin
- Myosin head (motor domain)
Pathways
Biological processes and signaling networks where the MYO1H gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MYO1H gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actin filament organization
- actin filament-based movement
- endocytosis
Cellular Component
Where in the cell the gene product is active
- myosin complex
- cytoplasm
- microvillus
- actin cytoskeleton
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- ATP binding
- microfilament motor activity