Myo1c Gene Summary [Mouse]

This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The protein functions in intracellular vesicle transport to the plasma membrane. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
Myo1c
Official Name
myosin IC [Source:MGI Symbol;Acc:MGI:106612]
Ensembl ID
ENSMUSG00000017774
Bio databases IDs NCBI: 17913 Ensembl: ENSMUSG00000017774
Aliases myosin IC
Synonyms LOC100365624, LOC686250, mm1beta, MMIb, MMI-beta, MMI-β, MYO1E, MyoIC, myosin 1C, myosin IC, Myosin I Heavy Chain, MYR2, Nm1, NMI
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myo1c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • phospholipid binding
  • IQ (isoleucine-glutamine) motif containing G and D (IQCG and IQCD)
  • calmodulin binding
  • Myosin and Kinesin motor domain
  • enzyme binding
  • microfilament motor protein
  • enzyme
  • protein binding
  • receptor binding
  • motor domain
  • Myosin head (motor domain)
  • actin filament binding
  • Calmodulin-binding motif
  • IQ domain
  • Unconventional myosin tail, actin- and lipid-binding
  • Myosin
  • cargo binding domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • prostate cancer
  • neoplasia
  • Alzheimer disease
  • familial nonsyndromic hearing impairment
  • pancreatic epithelial cancer
  • heart failure
  • idiopathic pulmonary fibrosis
  • rheumatoid arthritis
  • complete testicular feminization syndrome
  • ductal pancreatic cancer
regulated by
regulates
role in cell
  • expression in
  • proliferation
  • migration
  • molecular cleavage in
  • localization
  • ruffling
  • development
  • assembly
  • redistribution
  • dynamics

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • detergent resistant lipid raft fraction
  • caveolae-derived endocytic vesicles
  • cytoplasmic vesicle membrane
  • cellular membrane
  • Nucleus
  • Plasma Membrane
  • actin filaments
  • lipid droplets
  • cytosol
  • cortical cytoplasm
  • stereocilia
  • membrane ruffles
  • basal membrane
  • lateral plasma membrane
  • nucleoplasm
  • nucleoli
  • nuclear bodies
  • nuclear rim
  • neurites
  • membrane rafts
  • detergent insoluble microdomains
  • brush border
  • microvilli
  • exosomes
  • phagosomes

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Myo1c gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • positive regulation of protein targeting to membrane
  • vesicle transport along actin filament
  • positive regulation of cellular response to insulin stimulus
  • vascular endothelial growth factor signaling pathway
  • actin filament organization
  • cellular response to interferon-gamma
  • regulation of tight junction assembly
  • endocytosis
  • actin filament-based movement
  • protein targeting to membrane
  • positive regulation of cell migration

Cellular Component

Where in the cell the gene product is active
  • lateral plasma membrane
  • nuclear body
  • phagocytic vesicle
  • nucleolus
  • plasma membrane
  • nucleoplasm
  • cytoplasmic vesicle membrane
  • basal plasma membrane
  • extracellular vesicular exosome
  • brush border
  • microvillus
  • cytoplasm
  • cell cortex
  • stress fiber
  • membrane raft
  • membrane
  • actin cytoskeleton
  • unconventional myosin complex
  • ruffle membrane
  • cytosol
  • stereocilium membrane
  • filamentous actin

Molecular Function

What the gene product does at the molecular level
  • actin filament binding
  • ATP binding
  • calmodulin binding
  • protein binding
  • small GTPase binding
  • receptor binding
  • microfilament motor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.