Trmt2b Gene Summary [Mouse]
Enables rRNA (uridine-C5-)-methyltransferase activity and tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent. Predicted to be involved in rRNA methylation and tRNA processing. Located in mitochondrion. Is expressed in olfactory cortex ventricular layer and telencephalon ventricular layer. Orthologous to human TRMT2B (tRNA methyltransferase 2 homolog B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Trmt2b |
| Official Name | TRM2 tRNA methyltransferase 2B [Source:MGI Symbol;Acc:MGI:2442530] |
| Ensembl ID | ENSMUSG00000067369 |
| Bio databases IDs | |
| Aliases | TRM2 tRNA methyltransferase 2B |
| Synonyms | 4732479N06Rik, CXorf34, dJ341D10.3, RGD1565132, TRM2 tRNA methyltransferase 2B, tRNA methyltransferase 2 homolog B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trmt2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase
- rRNA (uridine) methyltransferase
- enzyme
- 23S rRNA (uracil-5-)-methyltransferase RumA
- protein binding
- methyltransferase domain
- C-methyltransferase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trmt2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA processing
- rRNA methylation
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- rRNA (uridine-C5-)-methyltransferase activity
- protein binding
- S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity