Tuba3a Gene Summary [Mouse]
Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Acts upstream of or within male germ-line stem cell population maintenance. Located in ciliary basal body and microtubule. Is expressed in several structures, including gonad; liver; lung; muscle tissue; and spleen. Human ortholog(s) of this gene implicated in keratoconus. Orthologous to several human genes including TUBA3D (tubulin alpha 3d). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tuba3a |
| Official Name | tubulin, alpha 3A [Source:MGI Symbol;Acc:MGI:1095406] |
| Ensembl ID | ENSMUSG00000067702 |
| Bio databases IDs | |
| Aliases | tubulin, alpha 3A |
| Synonyms | M[a]3, M[a]7, RGD1565155, Tuba3, Tuba3a, Tuba3b, Tuba7, tubulin, alpha 3A, tubulin, alpha 3B, tubulin, α 3A, tubulin, α 3B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tuba3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tubulin protein family of FtsZ and CetZ-like
- Tubulin C-terminal domain
- Tubulin/FtsZ family, GTPase domain
- Tubulin/FtsZ family, C-terminal domain
Pathways
Biological processes and signaling networks where the Tuba3a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- cilia
- basal bodies
- microtubules