Pex26 Gene Summary [Mouse]
This gene is a member of the peroxin-26 family. The encoded protein is probably required for protein import into peroxisomes. It may anchor Pex1 and Pex6 to peroxisome membranes. Defects in a similar gene in human are the cause of peroxisome biogenesis disorder complementation group 8 (PBD-CG8). PBD refers to a group of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2015]
Details
| Type | Protein Coding |
| Official Symbol | Pex26 |
| Official Name | peroxisomal biogenesis factor 26 [Source:MGI Symbol;Acc:MGI:1921293] |
| Ensembl ID | ENSMUSG00000067825 |
| Bio databases IDs | |
| Aliases | peroxisomal biogenesis factor 26 |
| Synonyms | 4632428M11RIK, PBD7A, PBD7B, peroxisomal biogenesis factor 26, PEX26M1T, Pex26p, Pex26pM1T |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pex26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase binding
- binding protein
- protein binding activity, bridging
- protein binding
- Pex26 protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peroxisome biogenesis disorder 7a (zellweger)
- peroxisome biogenesis disorder
- peroxisome biogenesis disorder 7B
- Zellweger syndrome
- infantile refsum disease
regulates
role in cell
- biogenesis in
- biogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- peroxisome membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pex26 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into peroxisome matrix
- protein to membrane docking
- protein import into peroxisome membrane
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- peroxisome
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein anchor
- ATPase binding