Daxx Gene Summary [Mouse]
Enables histone binding activity and transcription coactivator activity. Involved in several processes, including nucleosome assembly; positive regulation of transcription by RNA polymerase II; and protein localization to chromatin. Acts upstream of or within several processes, including apoptotic signaling pathway; negative regulation of DNA-templated transcription; and regulation of apoptotic process. Located in PML body and cytosol. Colocalizes with heterochromatin. Is expressed in several structures, including early embryo; genitourinary system; heart; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in appendiceal neoplasm; islet cell tumor; oral squamous cell carcinoma; ovary epithelial cancer; and pancreatic endocrine carcinoma. Orthologous to human DAXX (death domain associated protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Daxx |
| Official Name | Fas death domain-associated protein [Source:MGI Symbol;Acc:MGI:1197015] |
| Ensembl ID | ENSMUSG00000002307 |
| Bio databases IDs | |
| Aliases | Fas death domain-associated protein |
| Synonyms | BING2, DAP6, death-domain associated protein, EAP1, Fas death domain-associated protein, PML ASSOCIATED FACTOR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Daxx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- transcription co-repressor
- heat shock protein binding
- protein binding activity, bridging
- androgen receptor binding
- transcription factor binding
- coiled-coil domain
- Helical bundle domain of the death-domain associated protein (DAXX)
- serine-proline rich domain
- ubiquitin protein ligase binding
- histone binding
- protein kinase binding
- Daxx N-terminal Rassf1C-interacting domain
- nuclear localization sequence
- enzyme binding
- histone binding domain
- JUN kinase binding
- glutamic acid-rich domain
- protein binding
- p53 binding
- acidic domain
- kinesin binding
- protein kinase activator
- PEST domain
- apoptosis activation domain
- protein homodimerization
- Fas binding domain
- JNK activation domain
Pathways
Biological processes and signaling networks where the Daxx gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- autoinflammatory disorder
- neoplasia
- growth failure
- thyroid oncocytic carcinoma
- Hurthle cell thyroid cancer
- uterine leiomyosarcoma
- uterine cancer
- soft tissue sarcoma cancer
role in cell
- apoptosis
- production in
- expression in
- activation in
- cell death
- proliferation
- transcription in
- synthesis in
- phosphorylation in
- G0/G1 phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- ND10 structure
- heterochromatin
- Cytoplasm
- cell cortex
- Plasma Membrane
- microtubules
- cytosol
- nuclear foci
- nucleoplasm
- nuclear bodies
- sex chromatin
- nuclear speckles
- nuclear matrix
- PML nuclear bodies
- centromeres
- chromatin
- perikaryon
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Daxx gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription, DNA-dependent
- JNK cascade
- regulation of apoptotic process
- cellular response to copper ion
- induction of apoptosis via death domain receptors
- nucleosome assembly
- negative regulation of gene expression
- chromatin remodeling
- cellular response to heat
- negative regulation of transcription, DNA-dependent
- positive regulation of protein kinase activity
- positive regulation of transcription, DNA-dependent
- positive regulation of protein phosphorylation
- cellular response to cadmium ion
- regulation of gene expression
- cellular response to unfolded protein
- regulation of protein ubiquitination
- androgen receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- PML body
- cytosol
- chromosome, centromeric region
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- heat shock protein binding
- p53 binding
- ubiquitin protein ligase binding
- protein binding
- androgen receptor binding
- transcription coactivator activity
- histone binding
- transcription corepressor activity
- protein kinase activator activity
- enzyme binding