Ppp1cc Gene Summary [Mouse]
Enables protein serine/threonine phosphatase activity. Involved in circadian regulation of gene expression; entrainment of circadian clock by photoperiod; and protein dephosphorylation. Acts upstream of or within blastocyst development; regulation of nucleocytoplasmic transport; and spermatogenesis. Located in mitochondrial outer membrane. Is expressed in several structures, including central nervous system and retina. Orthologous to human PPP1CC (protein phosphatase 1 catalytic subunit gamma). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppp1cc |
| Official Name | protein phosphatase 1 catalytic subunit gamma [Source:MGI Symbol;Acc:MGI:104872] |
| Ensembl ID | ENSMUSG00000004455 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1 catalytic subunit gamma |
| Synonyms | EG434233, Gm5601, PP-1G, Ppp1cc, protein phosphatase 1 catalytic subunit gamma B, protein phosphatase 1 catalytic subunit γ B |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppp1cc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Serine-threonine protein phosphatase N-terminal domain
- protein kinase binding
- protein serine/threonine phosphatase
- phosphatase
- metallophosphatase superfamily, metallophosphatase domain
- Protein phosphatase 2A homologues, catalytic domain
- Calcineurin-like phosphoesterase
Pathways
Biological processes and signaling networks where the Ppp1cc gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- ATM Signaling
- Breast Cancer Regulation by Stathmin1
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cellular Effects of Sildenafil (Viagra)
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- EIF2 Signaling
- ERK/MAPK Signaling
- HIPPO signaling
- Insulin Receptor Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Protein Kinase A Signaling
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
regulated by
phenotypes
- decreased circulating free fatty acid level
- hypoactivity
- increased mean corpuscular hemoglobin
- male infertility
- abnormal locomotor activation
- abnormal male meiosis
- abnormal preimplantation embryo development
- abnormal seminiferous tubule morphology
- abnormal sperm fibrous sheath morphology
- abnormal sperm flagellum morphology
- abnormal sperm head morphology
- abnormal sperm midpiece morphology
- abnormal sperm mitochondrial sheath morphology
- abnormal sperm physiology
- abnormal sperm principal piece morphology
- abnormal spermatid morphology
- abnormal spermiogenesis
- absent sperm mitochondrial sheath
- arrest of spermiogenesis
- azoospermia
- decreased male germ cell number
- globozoospermia
- multiflagellated sperm
- oligozoospermia
- pinhead sperm
- small seminiferous tubules
- small testis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- nucleoli
- telomeres
- basement membrane