Prdm6 Gene Summary [Mouse]
Enables identical protein binding activity. Acts upstream of or within negative regulation of DNA-templated transcription; negative regulation of smooth muscle cell differentiation; and neurogenesis. Located in nucleus. Is expressed in several structures, including arterial system; extraembryonic component; genitourinary system; immune system; and trunk mesenchyme. Human ortholog(s) of this gene implicated in patent ductus arteriosus. Orthologous to human PRDM6 (PR/SET domain 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prdm6 |
| Official Name | PR domain containing 6 [Source:MGI Symbol;Acc:MGI:2684938] |
| Ensembl ID | ENSMUSG00000069378 |
| Bio databases IDs | |
| Aliases | PR domain containing 6 |
| Synonyms | Gm92, KMT8C, PDA3, PR domain containing 6, PRISM, PR/SET domain 6, RGD1559594 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prdm6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- Zinc-finger double domain
- SET domain
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiovascular disorder
- atrial fibrillation
- alopecia
- coronary artery disease
- hypertension
- bleeding
- male pattern hair loss
- breast carcinoma
- heart failure
- patent ductus arteriosus 3
regulates
- RNA polymerase II
- DNA promoter
- DNA endogenous promoter
role in cell
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prdm6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- regulation of gene expression
- negative regulation of smooth muscle cell differentiation
- neurogenesis
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- metal ion binding