Vps4b Gene Summary [Mouse]
Predicted to enable ATP hydrolysis activity and protein homodimerization activity. Involved in late endosomal microautophagy; multivesicular body assembly; and viral budding from plasma membrane. Acts upstream of or within several processes, including canonical Wnt signaling pathway; establishment of blood-brain barrier; and potassium ion transport. Located in cytosol. Is expressed in central nervous system; head; and migrating neural crest. Orthologous to human VPS4B (vacuolar protein sorting 4 homolog B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vps4b |
| Official Name | vacuolar protein sorting 4B [Source:MGI Symbol;Acc:MGI:1100499] |
| Ensembl ID | ENSMUSG00000009907 |
| Bio databases IDs | |
| Aliases | vacuolar protein sorting 4B |
| Synonyms | 8030489C12Rik, MIG1, SKD1, SKD1B, vacuolar protein sorting 4B, vacuolar protein sorting 4 homolog B, VPS4-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vps4b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MIT
- Vps4 C terminal oligomerization domain
- protein binding
- identical protein binding
- AAA+ lid domain
- ATPase
- Microtubule Interacting and Trafficking molecule domain
- MIT (microtubule interacting and transport) domain
- AAA domain (dynein-related subfamily)
- ATPase family associated with various cellular activities (AAA)
- binding protein
- protein homodimerization
- P-loop containing Nucleoside Triphosphate Hydrolases
- transporter
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- quantity
- production in
- assembly
- formation
- morphology
- abnormal morphology
- organization
- elongation
- trafficking
- biogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- endosomes
- centrosome
- Flemming body
- cytosol
- endosomal membrane
- spindle pole
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vps4b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fission
- vacuole organization
- protein transport
- protein depolymerization
- establishment of blood-brain barrier
- nucleus organization
- potassium ion transport
- non-lytic virus budding from plasma membrane
- regulation of centrosome duplication
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- angiogenesis
- plasma membrane repair
- autophagy
- endosomal transport
- multivesicular body sorting pathway
- endosome to lysosome transport via multivesicular body sorting pathway
- canonical Wnt receptor signaling pathway
- response to lipid
- nuclear envelope reassembly
- cholesterol transport
- mitotic metaphase plate congression
- macroautophagy
- positive regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- spindle pole
- plasma membrane
- nuclear pore
- late endosome membrane
- nucleus
- centrosome
- extracellular vesicular exosome
- endosome
- cytoplasm
- cytosol
- endosome membrane
- midbody
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- identical protein binding
- protein homodimerization activity
- protein binding