Cap2 Gene Summary [Mouse]
Predicted to enable actin binding activity; adenylate cyclase binding activity; and identical protein binding activity. Involved in presynaptic actin cytoskeleton organization. Located in postsynaptic density. Is expressed in several structures, including head mesenchyme; heart; metanephros; telencephalon; and vertebral axis musculature. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human CAP2 (cyclase associated actin cytoskeleton regulatory protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cap2 |
| Official Name | CAP, adenylate cyclase-associated protein, 2 (yeast) [Source:MGI Symbol;Acc:MGI:1914502] |
| Ensembl ID | ENSMUSG00000021373 |
| Bio databases IDs | |
| Aliases | CAP, adenylate cyclase-associated protein, 2 (yeast) |
| Synonyms | 2810452G09Rik, CMD2I, cyclase associated actin cytoskeleton regulatory protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cap2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Adenylate cyclase associated (CAP) N terminal
- Adenylate cyclase associated (CAP) C terminal
- Tubulin binding cofactor C
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- schizophrenia
- organismal death
- dilated cardiomyopathy type 2I
- primary gastric cancer
- neuroblastoma
- neuroblastoma formation
- gastric cancer
regulates
role in cell
- organization
- depolymerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- postsynaptic region
- postsynaptic density
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cap2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- cell morphogenesis
- establishment or maintenance of cell polarity
- actin filament organization
- activation of adenylate cyclase activity
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- actin binding
- adenylate cyclase binding