Cst7 Gene Summary [Mouse]
Enables cysteine-type endopeptidase inhibitor activity. Acts upstream of or within negative regulation of microglial cell activation and positive regulation of myelination. Located in several cellular components, including Golgi apparatus; late endosome; and lysosome. Is expressed in several structures, including early conceptus and female reproductive system. Orthologous to human CST7 (cystatin F). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cst7 |
| Official Name | cystatin F (leukocystatin) [Source:MGI Symbol;Acc:MGI:1298217] |
| Ensembl ID | ENSMUSG00000068129 |
| Bio databases IDs | |
| Aliases | cystatin F (leukocystatin) |
| Synonyms | CMAP, CYSTATIN F, cystatin F (leukocystatin), Leukocystatin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cst7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CY
- endopeptidase inhibitor
- cysteine protease inhibitor activity
- protease binding
- protease inhibitor
- protein homodimerization
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- amyloidosis
- tauopathy
- Down syndrome
- papillary thyroid carcinoma
- papillary thyroid cancer
- hypersensitive reaction
- infection by parasite
role in cell
- expression in
- apoptosis
- accumulation in
- number
- stabilization in
- function
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- endosomes
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- late endosomes
- cytoplasmic vesicles
- multivesicular bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cst7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- negative regulation of peptidase activity
- positive regulation of myelination
Cellular Component
Where in the cell the gene product is active
- extracellular space
- endosome
- late endosome
- cytoplasmic vesicle
- endoplasmic reticulum
- Golgi apparatus
- multivesicular body
- lysosome
Molecular Function
What the gene product does at the molecular level
- peptidase inhibitor activity
- endopeptidase inhibitor activity
- protein binding
- protein homodimerization activity
- cysteine-type endopeptidase inhibitor activity