Tpt1 Gene Summary [Mouse]
Enables DNA-binding transcription factor binding activity. Involved in negative regulation of ectoderm development and stem cell population maintenance. Located in nucleoplasm. Is expressed in cerebral cortex ventricular layer; cortical plate; sciatic nerve; and testis. Orthologous to several human genes including TPT1 (tumor protein, translationally-controlled 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tpt1 |
| Official Name | tumor protein, translationally-controlled 1 [Source:MGI Symbol;Acc:MGI:104890] |
| Ensembl ID | ENSMUSG00000060126 |
| Bio databases IDs | |
| Aliases | tumor protein, translationally-controlled 1 |
| Synonyms | FORTILIN, HRF, p02, p21, p23, TCTP, Tctp21, Trt, Tumor Protein Translationally-controlled 1, tumor protein, translationally-controlled 1, tumour Protein Translationally-controlled 1, tumour protein, translationally-controlled 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tpt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Translationally controlled tumour protein
- calcium ion binding
- TCTP homology region
- transcription factor binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- Alzheimer disease
- COVID-19
- acute graft-vs-host disease
- Parkinson disease
- non-small cell lung carcinoma
- non-small cell lung cancer
- hyperglycemia
- susceptibility to acute infection-induced (herpes-specific) encephalopathy 10
role in cell
- expression in
- migration
- apoptosis
- formation
- formation in
- proliferation
- growth
- cell death
- quantity
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- cell periphery
- perinuclear region
- Nucleus
- Plasma Membrane
- Mitochondria
- cytosol
- nucleoplasm
- nucleoli
- spindle pole
- multivesicular bodies
- cytoplasmic microtubule
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tpt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of apoptotic process
- calcium ion transport
- regulation of apoptotic process
- response to virus
- cellular calcium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- spindle pole
- cytosol
- cytoplasmic microtubule
- multivesicular body
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- calcium ion binding