Dsg1a Gene Summary [Mouse]
This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Jan 2016]
Details
| Type | Protein Coding |
| Official Symbol | Dsg1a |
| Official Name | desmoglein 1 alpha [Source:MGI Symbol;Acc:MGI:94930] |
| Ensembl ID | ENSMUSG00000069441 |
| Bio databases IDs | |
| Aliases | desmoglein 1 alpha |
| Synonyms | BB010119, desmoglein 1 alpha, desmoglein 1 beta, desmoglein 1 α, desmoglein 1 β, DG1, DGI, Dsg1, Dsg1a, dsg1-alpha, Dsg1b, dsg1-beta, dsg1-α, dsg1-β, Dsg5 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dsg1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cadherin, Y-type LIR-motif
- gamma-catenin binding
- Cadherin repeat-like domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- insoluble fractions
- Cytoplasm
- cell surface
- cell borders
- cellular membrane
- Nucleus
- intercellular junctions
- desmosomes
- cytoplasmic face of plasma membrane
- apical membrane
- lateral plasma membrane