Spink5 Gene Summary [Mouse]
Enables peptidase inhibitor activity. Acts upstream of or within negative regulation of serine-type peptidase activity and regulation of cell adhesion. Predicted to be located in several cellular components, including endoplasmic reticulum membrane; epidermal lamellar body; and perinuclear region of cytoplasm. Predicted to be active in extracellular region. Is expressed in back skin. Used to study Netherton syndrome. Human ortholog(s) of this gene implicated in Netherton syndrome. Orthologous to human SPINK5 (serine peptidase inhibitor Kazal type 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spink5 |
| Official Name | serine peptidase inhibitor, Kazal type 5 [Source:MGI Symbol;Acc:MGI:1919682] |
| Ensembl ID | ENSMUSG00000055561 |
| Bio databases IDs | |
| Aliases | serine peptidase inhibitor, Kazal type 5 |
| Synonyms | 2310065D10RIK, LEKT1, LEKTI, LETK1, LETKI, LOC100910851, NETS, NS, serine peptidase inhibitor Kazal type 5, serine peptidase inhibitor, Kazal type 5, VAKT1, VAKTI |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spink5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- serine proteinase inhibitory domain
- protease inhibitor
- serine protease inhibitor activity
- KAZAL_FS
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Netherton syndrome
- atopic dermatitis
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- hyperkeratosis
- acanthosis
- desquamation
- parakeratosis
- susceptibility to otitis media
- head and neck squamous cell carcinoma
role in cell
- adhesion
- differentiation
- organization
- abnormal morphology
- cleavage
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular membrane-bounded organelle
- Cytoplasm
- perinuclear region
- cell cortex
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- alveolar epithelial lamellar bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spink5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- multicellular organismal development
- negative regulation of proteolysis
- regulation of anagen
- epithelial cell differentiation
- regulation of T cell differentiation
- negative regulation of antibacterial peptide production
- epidermal cell differentiation
- central nervous system development
- cell differentiation
- extracellular matrix organization
- regulation of cell adhesion
- negative regulation of immune response
- hair cell differentiation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- cytoplasm
- intracellular membrane-bounded organelle
- cell cortex
- cytosol
- endoplasmic reticulum
- epidermal lamellar body
- extracellular region
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity