Fcho1 Gene Summary [Mouse]
Predicted to enable AP-2 adaptor complex binding activity. Predicted to be involved in several processes, including T cell receptor signaling pathway; clathrin coat assembly; and clathrin-dependent endocytosis. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in clathrin-coated pit; clathrin-coated vesicle; and plasma membrane. Is expressed in central nervous system; dorsal root ganglion; neural retina; and thymus primordium. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human FCHO1 (FCH and mu domain containing endocytic adaptor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fcho1 |
| Official Name | FCH domain only 1 [Source:MGI Symbol;Acc:MGI:1921265] |
| Ensembl ID | ENSMUSG00000070000 |
| Bio databases IDs | |
| Aliases | FCH domain only 1 |
| Synonyms | 3322402E17RIK, FCH and mu domain containing endocytic adaptor 1, FCH domain only 1, IMD76 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fcho1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- AP_MHD_Cterm
- Muniscin C-terminal mu homology domain
- Mu-homology domain
- Fes/CIP4, and EFC/F-BAR homology domain
- protein binding
- Bin/Amphiphysin/Rvs domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytosol
- nucleoplasm
- clathrin-coated pits
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fcho1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- clathrin-mediated endocytosis
- positive regulation of T cell activation
- clathrin coat assembly
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- coated pit
- cytosol
- clathrin-coated vesicle
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- AP-2 adaptor complex binding