Mapre3 Gene Summary [Mouse]
Enables microtubule plus-end binding activity. Involved in positive regulation of DNA-templated transcription and positive regulation of cyclin-dependent protein serine/threonine kinase activity. Located in cytoplasm; microtubule plus-end; and midbody. Colocalizes with microtubule. Orthologous to human MAPRE3 (microtubule associated protein RP/EB family member 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mapre3 |
| Official Name | microtubule-associated protein, RP/EB family, member 3 [Source:MGI Symbol;Acc:MGI:2140967] |
| Ensembl ID | ENSMUSG00000029166 |
| Bio databases IDs | |
| Aliases | microtubule-associated protein, RP/EB family, member 3 |
| Synonyms | EB2, EB3, EBF3, EBF3-S, microtubule associated protein RP/EB family member 3, microtubule-associated protein, RP/EB family, member 3, RP3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mapre3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calponin homology domain
- protein kinase binding
- central domain
- leucine zipper domain
- enzyme
- protein binding
- identical protein binding
- acidic domain
- EB1-like C-terminal motif
- protein kinase activator
- microtubule binding
- calponin homology (CH) domain superfamily
- microtubule plus-end binding
Pathways
Biological processes and signaling networks where the Mapre3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
role in cell
- invasion
- catastrophe
- stabilization
- cytokinesis
- cell spreading
- internalization by
- morphogenesis
- stabilization in
- shrinkage
- bundling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- perinuclear region
- centrosome
- microtubules
- midbody
- synapse
- cytoplasmic microtubule
- plus end of microtubule
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mapre3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- spindle assembly
- positive regulation of cyclin-dependent protein kinase activity
- positive regulation of transcription, DNA-dependent
- positive regulation of protein kinase activity
- protein localization to microtubule
- protein localization
- regulation of microtubule polymerization
- regulation of microtubule polymerization or depolymerization
Cellular Component
Where in the cell the gene product is active
- spindle midzone
- microtubule organizing center
- cytoplasm
- microtubule plus end
- midbody
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- protein binding
- microtubule plus-end binding
- microtubule binding