Ythdc1 Gene Summary [Mouse]
Predicted to enable N6-methyladenosine-containing RNA reader activity and mRNA binding activity. Involved in post-transcriptional regulation of gene expression. Acts upstream of or within several processes, including mRNA alternative polyadenylation; primary follicle stage; and regulation of alternative mRNA splicing, via spliceosome. Located in nucleus. Is expressed in brain; intestine; and liver. Orthologous to human YTHDC1 (YTH N6-methyladenosine RNA binding protein C1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ythdc1 |
| Official Name | YTH domain containing 1 [Source:MGI Symbol;Acc:MGI:2443713] |
| Ensembl ID | ENSMUSG00000035851 |
| Bio databases IDs | |
| Aliases | YTH domain containing 1 |
| Synonyms | A730098D12RIK, D9Mgi6, DKFZP761C1811, KIAA1966, mKIAA1966, YT521, YT521-B, YTH domain containing 1, YTH domain-containing protein 1, YTH N6-methyladenosine RNA binding protein C1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ythdc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EVE and YTH domains belong to the PUA superfamily
- protein binding activity, bridging
- protein binding
- YT521-B-like domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- colorectal cancer
- neoplasia
- metastasis
- pancreatic cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- bladder cancer
- ovarian cancer
- fibrosis
role in cell
- proliferation
- apoptosis
- S phase
- phosphorylation in
- expression in
- binding in
- migration
- senescence
- invasion by
- splicing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- nucleoplasm
- nuclear bodies
- interchromatin granule clusters
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ythdc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- posttranscriptional regulation of gene expression
- in utero embryonic development
- regulation of alternative nuclear mRNA splicing, via spliceosome
- spermatogenesis
- regulation of nuclear mRNA splicing, via spliceosome
- mRNA splice site selection
- dosage compensation by inactivation of X chromosome
- primary follicle stage
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding