Gprasp2 Gene Summary [Mouse]
Enables amyloid-beta binding activity. Acts upstream of or within hematopoietic stem cell homeostasis. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in central nervous system and neural retina. Used to study autism spectrum disorder and intellectual disability. Human ortholog(s) of this gene implicated in X-linked deafness 7. Orthologous to several human genes including GPRASP2 (G protein-coupled receptor associated sorting protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Gprasp2 |
| Official Name | G protein-coupled receptor associated sorting protein 2 [Source:MGI Symbol;Acc:MGI:2442071] |
| Ensembl ID | ENSMUSG00000072966 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor associated sorting protein 2 |
| Synonyms | 5330440H13RIK, DFNX7, GASP-2, G protein-coupled receptor associated sorting protein 2, Prpl5, RGD1561019 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gprasp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein-coupled receptor binding
- protein binding
- beta-amyloid binding
- Armadillo-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gprasp2 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- protein binding
- beta-amyloid binding