Ksr2 Gene Summary [Mouse]
Enables MAP-kinase scaffold activity and mitogen-activated protein kinase kinase binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within calcium-mediated signaling and positive regulation of MAPK cascade. Located in cytosol and plasma membrane. Orthologous to human KSR2 (kinase suppressor of ras 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Ksr2 |
| Official Name | kinase suppressor of ras 2 [Source:MGI Symbol;Acc:MGI:3610315] |
| Ensembl ID | ENSMUSG00000061578 |
| Bio databases IDs | |
| Aliases | kinase suppressor of ras 2 |
| Synonyms | kinase suppressor of ras 2, RGD1562674 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ksr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- SAM like domain present in kinase suppressor RAS 1
- MAP-kinase scaffold protein
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- Kinase suppressor RAS 1 N-terminal helical hairpin
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- psoriasis
- obesity
- non-insulin-dependent diabetes mellitus
- male pattern hair loss
- early-onset obesity
- coronary artery disease
- insomnia
- late-onset Alzheimer disease
- refractive error
role in cell
- differentiation
- phosphorylation in
- formation
- formation in
- apoptosis
- activation in
- production in
- signaling in
- depletion in
- depletion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ksr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- Ras protein signal transduction
- positive regulation of MAPK cascade
- calcium-mediated signaling
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- protein kinase activity
- MAP-kinase scaffold activity
- protein serine/threonine kinase activity
- mitogen-activated protein kinase kinase binding