Nfkbiz Gene Summary [Mouse]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and transcription coregulator activity. Involved in several processes, including lymphocyte activation involved in immune response; positive regulation of immune response; and response to bacterium. Acts upstream of or within inflammatory response. Is active in nucleus. Is expressed in central nervous system; early conceptus; eye; and genitourinary system. Used to study Stevens-Johnson syndrome and atopic dermatitis. Orthologous to human NFKBIZ (NFKB inhibitor zeta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nfkbiz |
| Official Name | nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta [Source:MGI Symbol;Acc:MGI:1931595] |
| Ensembl ID | ENSMUSG00000035356 |
| Bio databases IDs | |
| Aliases | nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta |
| Synonyms | I-kappa-B-zeta, IkappaB-ζ, IKBZ, IKB zeta, IKB ζ, INAP, I-κ-B-ζ, MAIL, NFKB inhibitor zeta, NFKB inhibitor ζ, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta, nuclear factor of κ light polypeptide gene enhancer in B cells inhibitor, ζ, RGD1310834 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nfkbiz often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- nucleic acid binding
- double-stranded DNA binding
- Ankyrin repeats (3 copies)
- transcription cofactor
- protein binding
- sequence-specific DNA binding
- Ankyrin repeat
Pathways
Biological processes and signaling networks where the Nfkbiz gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- experimental autoimmune encephalomyelitis
- COVID-19
- chronic kidney disease
- epithelial cancer
- inflammatory bowel disease
- colorectal cancer
- ulcerative colitis
- Alzheimer disease
- acanthosis
role in cell
- growth
- differentiation
- expression in
- proliferation
- production in
- apoptosis
- induction in
- binding in
- cell death
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytoplasmic ribonucleoprotein granule
- nuclear foci
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nfkbiz gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spleen development
- response to xenobiotic stimulus
- positive regulation of transcription from RNA polymerase II promoter
- execution phase of apoptosis
- establishment of skin barrier
- T cell mediated immunity
- chromatin remodeling
- plasma cell differentiation
- cytokine-mediated signaling pathway
- keratinocyte activation
- T cell receptor signaling pathway
- isotype switching
- mRNA transcription from RNA polymerase II promoter
- response to cisplatin
- keratinocyte proliferation
- defense response to Gram-negative bacterium
- positive regulation of inflammatory response
- B cell proliferation
- T-helper 1 cell differentiation
- toll-like receptor signaling pathway
- cellular response to transforming growth factor beta stimulus
- chronic inflammatory response
- keratinocyte differentiation
- cellular response to lipopolysaccharide
- homeostasis of number of cells within a tissue
- response to folic acid
- regulation of gene expression
- positive regulation of T-helper 17 cell differentiation
- DNA-dependent transcriptional preinitiation complex assembly
- T-helper 17 cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription cofactor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- POU domain binding