Cox7a1 Gene Summary [Mouse]
Contributes to cytochrome-c oxidase activity. Involved in oxidative phosphorylation. Located in mitochondrion. Part of respiratory chain complex IV. Is expressed in several structures, including aorta; brown fat; heart; lung; and metanephros. Used to study dilated cardiomyopathy. Orthologous to human COX7A1 (cytochrome c oxidase subunit 7A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cox7a1 |
| Official Name | cytochrome c oxidase subunit 7A1 [Source:MGI Symbol;Acc:MGI:1316714] |
| Ensembl ID | ENSMUSG00000074218 |
| Bio databases IDs | |
| Aliases | cytochrome c oxidase subunit 7A1 |
| Synonyms | COX7A, COX7AH, COX7AM, CoxVIIa-M, cytochrome c oxidase subunit 7A1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cox7a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome-c oxidase
- Cyt_c_Oxidase_VIIa
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Cox7a1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bladder cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- lung squamous cell carcinoma
- squamous cell lung cancer
- colon epithelial cancer
- dilated cardiomyopathy
- renal cell cancer
regulates
role in cell
- respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cox7a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of precursor metabolites and energy
- regulation of oxidative phosphorylation
- mitochondrial electron transport, cytochrome c to oxygen
- mitochondrial respiratory chain supercomplex assembly
Cellular Component
Where in the cell the gene product is active
- mitochondrial respiratory chain
- mitochondrion
- mitochondrial respiratory chain complex IV
Molecular Function
What the gene product does at the molecular level
- cytochrome-c oxidase activity
- protein binding