Sdhb Gene Summary [Mouse]
Predicted to enable iron-sulfur cluster binding activity; succinate dehydrogenase (quinone) activity; and ubiquinone binding activity. Predicted to be involved in aerobic respiration; respiratory electron transport chain; and succinate metabolic process. Located in mitochondrion. Part of respiratory chain complex II (succinate dehydrogenase). Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; mitochondrial complex II deficiency; paraganglioma; and pheochromocytoma. Orthologous to human SDHB (succinate dehydrogenase complex iron sulfur subunit B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sdhb |
| Official Name | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) [Source:MGI Symbol;Acc:MGI:1914930] |
| Ensembl ID | ENSMUSG00000009863 |
| Bio databases IDs | |
| Aliases | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) |
| Synonyms | 0710008N11Rik, CII-30, CII - 30 (Fe S), CWS2, Electron-transfer-flavoprotein, beta polypeptide, Electron-transfer-flavoprotein, β polypeptide, IP, MC2DN4, PCHC, PGL4, PPGL4, SDH, SDH1, SDH2, SDH30, SDHIP, succinate dehydrogenase complex iron sulfur subunit B, succinate dehydrogenase complex iron sulphur subunit B, Succinate dehydrogenase complex subunit B, succinate dehydrogenase complex, subunit B, iron sulfur (Ip), succinate dehydrogenase complex, subunit B, iron sulphur (Ip), Succinate Dehydrogenase Cytochrome B Subunit, Succinate Dehydrogenase lp Cytochrome B Subunit, Succinate dehydrogenase putative iron sulfur subunit, Succinate dehydrogenase putative iron sulphur subunit, SUHB |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sdhb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 4Fe-4S dicluster domain
- fer2
- binding protein
- ubiquinone binding
- succinate dehydrogenase and fumarate reductase iron-sulfur protein
- 2Fe-2S iron-sulfur cluster binding domain
- enzyme
- protein binding
- succinate dehydrogenase (ubiquinone)
- succinate dehydrogenase
Pathways
Biological processes and signaling networks where the Sdhb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- abdominal cancer
- cancer
- epithelial cancer
- gastrointestinal stromal neoplasia
- hereditary cancer-predisposing syndrome
- hereditary paraganglioma-pheochromocytoma syndrome
- Huntington disease
- extra-adrenal paraganglioma formation
- paraganglioma formation
regulated by
- lipopolysaccharide
- palmitic acid
- DYRK1B
- cisplatin
- BAG3
- butyric acid
- isobutylmethylxanthine
- ompenaclid
- 2500002B13Rik
- poly rI:rC-RNA
role in cell
- expression in
- production in
- proliferation
- growth
- phosphorylation in
- cell death
- survival
- invasiveness
- downregulation in
- hypermethylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Plasma Membrane
- Mitochondria
- cytosol
- mitochondrial matrix
- mitochondrial inner membrane
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sdhb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- respiratory electron transport chain
- mitochondrial electron transport, succinate to ubiquinone
- tricarboxylic acid cycle
- aerobic respiration
- mitochondrial ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- respiratory chain complex II
- mitochondrial membrane
- mitochondrion
- plasma membrane
- mitochondrial inner membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- succinate dehydrogenase (ubiquinone) activity
- metal ion binding
- electron carrier activity
- 3 iron, 4 sulfur cluster binding
- ubiquinone binding
- 4 iron, 4 sulfur cluster binding
- 2 iron, 2 sulfur cluster binding