FAT3 Gene Summary [Human]
Predicted to enable calcium ion binding activity. Predicted to be involved in cell-cell adhesion. Predicted to act upstream of or within several processes, including negative regulation of dendrite development; neuron migration; and retina layer formation. Predicted to be located in dendrite and plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | FAT3 |
| Official Name | FAT atypical cadherin 3 [Source:HGNC Symbol;Acc:HGNC:23112] |
| Ensembl ID | ENSG00000165323 |
| Bio databases IDs | |
| Aliases | FAT atypical cadherin 3, cadherin-related family member 10 |
| Synonyms | 9430076A06, 9430076A06Rik, CDHF15, CDHR10, D430038H04RIK, FAT atypical cadherin 3, Gm1132, Gm510, hFat3, MFAT3F |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FAT3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cadherin-like
- LamG
- Human growth factor-like EGF
- Cadherin repeat-like domain
- laminin G domain
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- non-insulin-dependent diabetes mellitus
- hepatocellular carcinoma
- liver cancer
- schizophrenia
- peripheral neuropathy
- prostate cancer
- retinal detachment
- postoperative nausea and vomiting
regulates
- CD8 (family)
role in cell
- development
- abnormal morphology
- morphogenesis
- Clathrin mediated endocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FAT3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of dendrite development
- retina layer formation
- cell morphogenesis involved in neuron differentiation
- homophilic cell adhesion
- dendrite development
Cellular Component
Where in the cell the gene product is active
- dendrite
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium ion binding