Tcf15

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding activity; and bHLH transcription factor binding activity. Contributes to DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II; regulation of stem cell differentiation; and stem cell population maintenance. Acts upstream of or within several processes, including epithelial cell differentiation; paraxial mesoderm development; and post-anal tail morphogenesis. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including early embryo; foregut-midgut junction; genitourinary system; paraxial mesenchyme; and sensory organ. Orthologous to human TCF15 (transcription factor 15). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tcf15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Tcf15 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Tcf15 gene, providing context for its role in the cell.