Mdm4 Gene Summary [Mouse]
This gene encodes a protein that has been shown to negatively regulate the activity of the tumor suppressor protein p53. Homozygous knockout mice exhibit embryonic lethality as a result of p53-dependent apoptosis and cell cycle arrest. Amplification of this gene or overexpression of the encoded protein has been linked to a range of human cancers. A pseudogene has been identified on the X chromosome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Details
| Type | Protein Coding |
| Official Symbol | Mdm4 |
| Official Name | transformed mouse 3T3 cell double minute 4 [Source:MGI Symbol;Acc:MGI:107934] |
| Ensembl ID | ENSMUSG00000054387 |
| Bio databases IDs | |
| Aliases | transformed mouse 3T3 cell double minute 4 |
| Synonyms | 4933417N07RIK, BMFS6, HDMX, LOC102633382, MDM4 regulator of p53, MDMX, MRP1, transformed mouse 3T3 cell double minute 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mdm4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- enzyme binding
- protein binding
- Mdm2 protein binding domain
- acidic domain
- phosphorylation site
- Zn-finger in Ran binding protein and others
- zinc ion binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- zinc finger domain
- p53-binding domain
- SWIB/MDM2 domain family
- Zinc finger, C3HC4 type (RING finger)
Pathways
Biological processes and signaling networks where the Mdm4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- thrombocytopenia
- tumorigenesis
- actinic keratosis
- metastatic breast cancer
- colon cancer
- melanoma cancer
- cancer
- prostate cancer
- Alzheimer disease
role in cell
- cell death
- apoptosis
- expression in
- proliferation
- colony formation
- degradation in
- loss
- cell viability
- phosphorylation in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mdm4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- heart valve development
- atrioventricular valve morphogenesis
- negative regulation of cell proliferation
- ventricular septum development
- atrial septum development
- negative regulation of protein catabolic process
- endocardial cushion morphogenesis
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- negative regulation of apoptotic process
- DNA damage response, signal transduction by p53 class mediator
- regulation of cell cycle
- cellular response to hypoxia
- protein stabilization
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcriptional repressor complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- protein binding
- enzyme binding