Slc4a11 Gene Summary [Mouse]
Predicted to enable several functions, including active borate transmembrane transporter activity; monoatomic cation channel activity; and water transmembrane transporter activity. Involved in fluid transport; monoatomic ion homeostasis; and regulation of mesenchymal stem cell differentiation. Located in basolateral plasma membrane. Is expressed in metanephros and vomeronasal organ. Used to study congenital hereditary endothelial dystrophy of cornea. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy; congenital hereditary endothelial dystrophy of cornea; and corneal dystrophy-perceptive deafness syndrome. Orthologous to human SLC4A11 (solute carrier family 4 member 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc4a11 |
| Official Name | solute carrier family 4, sodium bicarbonate transporter-like, member 11 [Source:MGI Symbol;Acc:MGI:2138987] |
| Ensembl ID | ENSMUSG00000074796 |
| Bio databases IDs | |
| Aliases | solute carrier family 4, sodium bicarbonate transporter-like, member 11 |
| Synonyms | BTR1, CDPD1, CHED, CHED2, dJ794I6.2, NABC1, Slc4a11 predicted, solute carrier family 4 member 11, solute carrier family 4, sodium bicarbonate transporter-like, member 11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc4a11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein dimerization
- HCO3- transporter family
- hydrogen ion transporter
- boron transporter
- sodium channel
- water transporter
- bicarbonate transporter
- transporter
- hydrogen ion channel
Pathways
Biological processes and signaling networks where the Slc4a11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- liver cancer
- congenital hereditary endothelial dystrophy,ched 2
- posterior polymorphous corneal dystrophy type 1
- Harboyan syndrome
- organismal death
- fuchs endothelial corneal dystrophy type 4
- refractive error
- hepatocellular carcinoma
role in cell
- differentiation
- senescence
- disorganization
- morphology
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- vesicle membrane
- apical membrane
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc4a11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- fluid transport
- anion transport
- borate transport
- regulation of mesenchymal stem cell differentiation
- sodium ion transport
- water transport
- cellular hypotonic response
- regulation of mitochondrial membrane potential
- cellular response to oxidative stress
- sodium ion transmembrane transport
- ion homeostasis
- borate transmembrane transport
- cellular cation homeostasis
- bicarbonate transport
Cellular Component
Where in the cell the gene product is active
- vesicle membrane
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane transporter activity
- hydrogen ion transmembrane transporter activity
- water transmembrane transporter activity
- hydrogen ion channel activity
- sodium channel activity
- symporter activity
- protein dimerization activity
- inorganic anion exchanger activity
- borate transmembrane transporter activity
- bicarbonate transmembrane transporter activity