Cyp3a41b Gene Summary [Mouse]
Predicted to enable demethylase activity; retinoic acid 4-hydroxylase activity; and steroid hydroxylase activity. Acts upstream of or within response to bacterium. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; and essential hypertension. Orthologous to human CYP3A5 (cytochrome P450 family 3 subfamily A member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp3a41b |
| Official Name | cytochrome P450, family 3, subfamily a, polypeptide 41B [Source:MGI Symbol;Acc:MGI:3714859] |
| Ensembl ID | ENSMUSG00000075552 |
| Bio databases IDs | |
| Aliases | cytochrome P450, family 3, subfamily a, polypeptide 41B |
| Synonyms | AABR07035343.1, cDEX, CYP, Cyp3a, Cyp3a1, Cyp3a16, Cyp3a2, Cyp3a23, Cyp3a23-3a1, Cyp3a23/3a1, Cyp3a3, Cyp3a4, Cyp3a41, Cyp3a41a, Cyp3a41b, Cyp3a44, cytochrome P450, family 3, subfamily a, polypeptide 11, cytochrome P450, family 3, subfamily a, polypeptide 16, cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1, cytochrome P450, family 3, subfamily a, polypeptide 41A, cytochrome P450, family 3, subfamily a, polypeptide 41B, cytochrome P450, family 3, subfamily a, polypeptide 44, IIIAm1, LOC100910877, Pcn, RL33 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cyp3a41b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- reduced flavin or flavoprotein:oxygen oxidoreductase
- testosterone 6 beta-hydroxylase
- oxidoreductase
- retinoic acid 4-hydroxylase
- monooxygenase
- demethylase activity
- enzyme
- steroid hydroxylase
Pathways
Biological processes and signaling networks where the Cyp3a41b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- xenobiotic
- midazolam
- 1-hydroxymethylmidazolam
- testosterone
- desethylamiodarone
- amiodarone
- lithocholic acid
- 3-keto lithocholic acid
- ochratoxin A
- triazolam
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- endoplasmic reticulum membrane
- microsome
- Golgi membrane