Ptpn23 Gene Summary [Mouse]
Predicted to enable protein kinase binding activity and protein tyrosine phosphatase activity. Predicted to be involved in several processes, including endosomal transport; positive regulation of adherens junction organization; and positive regulation of transport. Predicted to be located in ciliary basal body; early endosome; and nuclear body. Predicted to be active in endosome. Is expressed in several structures, including alimentary system; central nervous system; gonad; respiratory system epithelium; and skin. Orthologous to human PTPN23 (protein tyrosine phosphatase non-receptor type 23). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptpn23 |
| Official Name | protein tyrosine phosphatase, non-receptor type 23 [Source:MGI Symbol;Acc:MGI:2144837] |
| Ensembl ID | ENSMUSG00000036057 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, non-receptor type 23 |
| Synonyms | AI462446, Aw120888, HD-PTP, NEDBASS, p164 Ptp-Td14, protein tyrosine phosphatase non-receptor type 23, protein tyrosine phosphatase, non-receptor type 23, PTP-TD14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptpn23 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein-interacting V-domain of mammalian Alix and related domains
- protein kinase binding
- protein-tyrosine-phoshatase
- catalytic domain
- ALIX V-shaped domain binding to HIV
- Protein tyrosine phosphatase, catalytic domain
- PTP_DSP_cys
- protein binding
- Protein tyrosine phosphatase, catalytic domain motif
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-interacting Bro1-like domain of mammalian Alix and related domains
- Protein-tyrosine phosphatase
- BRO1-like domain
- phosphatase
Pathways
Biological processes and signaling networks where the Ptpn23 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- neoplasia
- pancreatic adenocarcinoma
- metastasis
- chronic lymphocytic leukemia
- lung cancer
- organismal death
- neurodevelopmental disorder and structural brain anomalies with or without seizures and spasticity
- cutaneous melanoma
- hereditary spastic paraplegia
role in cell
- expression in
- cell viability
- apoptosis
- survival
- proliferation
- growth
- phosphorylation in
- migration
- scattering
- cell-cell adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Nucleus
- basal bodies
- endosomes
- centrosome
- cytosol
- nucleoplasm
- nuclear bodies
- early endosomes
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptpn23 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- cilium morphogenesis
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- early endosome to late endosome transport
- negative regulation of epithelial cell migration
- positive regulation of early endosome to late endosome transport
- positive regulation of Wnt protein secretion
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- nucleus
- early endosome
- endosome
- nuclear body
- extracellular vesicular exosome
- cytoplasm
- cilium basal body
- intracellular membrane-bounded organelle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- protein tyrosine phosphatase activity