Zc3h3 Gene Summary [Mouse]
Enables R-SMAD binding activity. Acts upstream of or within mRNA 3'-end processing and positive regulation of activin receptor signaling pathway. Part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in central nervous system and genitourinary system. Orthologous to human ZC3H3 (zinc finger CCCH-type containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zc3h3 |
| Official Name | zinc finger CCCH type containing 3 [Source:MGI Symbol;Acc:MGI:2663721] |
| Ensembl ID | ENSMUSG00000075600 |
| Bio databases IDs | |
| Aliases | zinc finger CCCH type containing 3 |
| Synonyms | Kiaa0150, SMICL, ZC3HDC3, zinc finger CCCH-type containing 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zc3h3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- zinc finger
- Zinc finger C-x8-C-x5-C-x3-H type (and similar)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zc3h3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of activin receptor signaling pathway
- mRNA 3'-end processing
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- mRNA cleavage and polyadenylation specificity factor complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- metal ion binding
- R-SMAD binding