ZC3H3 Gene Summary [Human]
Predicted to enable SMAD binding activity. Involved in regulation of mRNA polyadenylation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZC3H3 |
| Official Name | zinc finger CCCH-type containing 3 [Source:HGNC Symbol;Acc:HGNC:28972] |
| Ensembl ID | ENSG00000014164 |
| Bio databases IDs | |
| Aliases | zinc finger CCCH-type containing 3 |
| Synonyms | Kiaa0150, SMICL, ZC3HDC3, zinc finger CCCH-type containing 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZC3H3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- zinc finger
- Zinc finger C-x8-C-x5-C-x3-H type (and similar)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZC3H3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of activin receptor signaling pathway
- mRNA 3'-end processing
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- mRNA cleavage and polyadenylation specificity factor complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- metal ion binding
- R-SMAD binding