Mlf1 Gene Summary [Mouse]
Enables DNA binding activity. Involved in DNA-templated transcription and myeloid progenitor cell differentiation. Located in several cellular components, including ciliary basal body; motile cilium; and non-motile cilium. Is active in ciliary base. Is expressed in several structures, including brain; gonad; immune system; lung; and nasal cavity respiratory epithelium. Orthologous to human MLF1 (myeloid leukemia factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mlf1 |
| Official Name | myeloid leukemia factor 1 [Source:MGI Symbol;Acc:MGI:1341819] |
| Ensembl ID | ENSMUSG00000048416 |
| Bio databases IDs | |
| Aliases | myeloid leukemia factor 1 |
| Synonyms | HLS7, myeloid leukaemia factor 1, myeloid leukemia factor 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mlf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 14-3-3 binding domain
- protein domain specific binding
- Myelodysplasia-myeloid leukemia factor 1-interacting protein
- protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- Ullrich congenital muscular dystrophy
- organismal death
- amyotrophic lateral sclerosis
- Huntington disease
role in cell
- expression in
- apoptosis
- proliferation
- growth
- phosphorylation in
- differentiation
- invasion by
- maturation
- cell cycle progression
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- motile cilia
- non-motile cilium
- Cytoplasm
- cilia
- perinuclear region
- basal bodies
- centrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mlf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription, DNA-dependent
- myeloid progenitor cell differentiation
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cilium basal body
- cilium
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein domain specific binding
- protein binding