Rad1 Gene Summary [Mouse]
Predicted to enable double-stranded DNA 3'-5' DNA exonuclease activity. Predicted to be involved in DNA repair; cellular response to ionizing radiation; and negative regulation of cell cycle phase transition. Predicted to be located in chromosome and nucleoplasm. Predicted to be part of checkpoint clamp complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Orthologous to human RAD1 (RAD1 checkpoint DNA exonuclease). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rad1 |
| Official Name | RAD1 checkpoint DNA exonuclease [Source:MGI Symbol;Acc:MGI:1316678] |
| Ensembl ID | ENSMUSG00000022248 |
| Bio databases IDs | |
| Aliases | RAD1 checkpoint DNA exonuclease |
| Synonyms | HRAD1, mRAD1, RAD1 checkpoint DNA exonuclease, REC1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rad1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta_clamp
- damaged DNA binding
- enzyme
- protein binding
- Repair protein Rad1/Rec1/Rad17
Pathways
Biological processes and signaling networks where the Rad1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
- brain cancer
role in cell
- cell viability
- accumulation in
- DNA damage response
- Gap 0-Gap 1 phase
- response by
- cohesion in
- cohesion
- accumulation
- checkpoint control
- cell survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- nuclear foci
- chromosome
- nucleoplasm
- synaptonemal complexes
- chromosomal cores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rad1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- meiotic recombination checkpoint
- DNA repair
- DNA damage checkpoint
- cellular response to ionizing radiation
- response to DNA damage stimulus
- substantia nigra development
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- chromosome
- nucleoplasm
- checkpoint clamp complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- double-stranded DNA specific 3'-5' exodeoxyribonuclease activity
- damaged DNA binding