Dpm1 Gene Summary [Mouse]
Enables dolichyl-phosphate beta-D-mannosyltransferase activity. Acts upstream of or within GPI anchor biosynthetic process; dolichol metabolic process; and response to oxygen levels. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of dolichol-phosphate-mannose synthase complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ie. Orthologous to human DPM1 (dolichyl-phosphate mannosyltransferase subunit 1, catalytic). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dpm1 |
| Official Name | dolichol-phosphate (beta-D) mannosyltransferase 1 [Source:MGI Symbol;Acc:MGI:1330239] |
| Ensembl ID | ENSMUSG00000078919 |
| Bio databases IDs | |
| Aliases | dolichol-phosphate (beta-D) mannosyltransferase 1 |
| Synonyms | CDGIE, dolichyl-phosphate mannosyltransferase subunit 1, catalytic, MPDS, MPD synthase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dpm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyl transferase family 2
- dolichyl-phosphate beta-D-mannosyltransferase
- binding protein
- metal ion binding
- enzyme
- protein binding
- Glycosyltransferase like family 2
- glycosyltransferase family A
- mannose binding
- dolichyl-phosphate-mannose-protein mannosyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostate cancer
- congenital disorder of glycosylation type 1e
- colon cancer
- prostatic carcinoma
- hereditary disorder
- infection by HIV-1
- productive infection by HIV-1
regulates
- dolichol 20
- asparagine
- GDP-D-mannose
role in cell
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dpm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- GPI anchor biosynthetic process
- GDP-mannose metabolic process
- protein N-linked glycosylation via asparagine
- protein mannosylation
- dolichol metabolic process
- protein O-linked mannosylation
- dolichol-linked oligosaccharide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- membrane
- dolichol-phosphate-mannose synthase complex
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- mannose binding
- protein binding
- metal ion binding
- alcohol binding
- dolichyl-phosphate beta-D-mannosyltransferase activity
- dolichyl-phosphate-mannose-protein mannosyltransferase activity