Siae Gene Summary [Mouse]
Predicted to enable sialate O-acetylesterase activity. Predicted to be involved in carbohydrate metabolic process and regulation of immune system process. Located in lysosome. Is expressed in several structures, including abdominal fat pad; central nervous system; genitourinary system; immune system; and yolk sac. Human ortholog(s) of this gene implicated in autoimmune disease. Orthologous to human SIAE (sialic acid acetylesterase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Siae |
| Official Name | sialic acid acetylesterase [Source:MGI Symbol;Acc:MGI:104803] |
| Ensembl ID | ENSMUSG00000001942 |
| Bio databases IDs | |
| Aliases | sialic acid acetylesterase |
| Synonyms | AIS6, CSE-C, LSE, RGD1310431, sialic acid acetylesterase, YSG2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Siae often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Carbohydrate esterase, sialic acid-specific acetylesterase
- sialate O-acetylesterase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- susceptibility to autoimmune disease type 6
- bipolar disorder
- schizophrenia
- Parkinson disease
regulated by
- Mrc 5 cells
- epigallocatechin-gallate
- LYSET
- CLN3
- tetrandrine
- fangchinoline
- cepharanthine
role in cell
- proliferation
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lysosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Siae gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- regulation of immune system process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- lysosome
Molecular Function
What the gene product does at the molecular level
- sialate O-acetylesterase activity