Insl5 Gene Summary [Mouse]
Predicted to enable G protein-coupled receptor binding activity. Acts upstream of or within positive regulation of feeding behavior. Located in collagen-containing extracellular matrix. Is expressed in several structures, including adipose tissue; brain; gut; hemolymphoid system gland; and retina. Orthologous to human INSL5 (insulin like 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Insl5 |
| Official Name | insulin-like 5 [Source:MGI Symbol;Acc:MGI:1346085] |
| Ensembl ID | ENSMUSG00000066090 |
| Bio databases IDs | |
| Aliases | insulin-like 5 |
| Synonyms | insulin-like 5, LOC102554482, PRO182, RIF2, UNQ156 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Insl5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IlGF_like
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- organismal death
- asthenozoospermia
- polyuria
- nasopharyngeal carcinoma
- nasopharyngeal cancer
- hyperglycemia
role in cell
- expression in
- proliferation
- quantity
- phosphorylation in
- glycolysis in
- number
- motility
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Insl5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- positive regulation of feeding behavior
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- protein binding
- hormone activity