Gypc Gene Summary [Mouse]
Located in cortical cytoskeleton and membrane. Is expressed in central nervous system; liver lobe; and pancreas mesenchyme. Human ortholog(s) of this gene implicated in malaria. Orthologous to human GYPC (glycophorin C (Gerbich blood group)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gypc |
| Official Name | glycophorin C [Source:MGI Symbol;Acc:MGI:1098566] |
| Ensembl ID | ENSMUSG00000090523 |
| Bio databases IDs | |
| Aliases | glycophorin C |
| Synonyms | 0610037F22RIK, CD236, CD236R, GE, glycophorin C, glycophorin C (Gerbich blood group), GPC, GPD, GYPD, PAS-2, PAS-2' |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gypc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- putative band 4.1 homologues' binding motif
- cytoplasmic domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriatic arthritis
- lung squamous cell carcinoma
- colon adenocarcinoma
- squamous cell lung cancer
- lung adenocarcinoma
- urothelial bladder carcinoma
- rectum cancer
- atrial fibrillation
- colon epithelial cancer
- colorectal carcinomagenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cortical cytoskeleton
- cell surface
- cellular membrane
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gypc gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
- cortical cytoskeleton
Molecular Function
What the gene product does at the molecular level
- protein binding