Rps27 Gene Summary [Mouse]
A structural constituent of ribosome. Involved in translation at postsynapse and translation at presynapse. Part of cytosolic small ribosomal subunit. Is active in postsynapse; presynapse; and ribosome. Is expressed in central nervous system; pancreas epithelium; and retina. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 17. Orthologous to human RPS27 (ribosomal protein S27). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rps27 |
| Official Name | ribosomal protein S27 [Source:MGI Symbol;Acc:MGI:1888676] |
| Ensembl ID | ENSMUSG00000090733 |
| Bio databases IDs | |
| Aliases | ribosomal protein S27 |
| Synonyms | 3200001M24Rik, 40S Ribosomal Protein S27, DBA17, eS27, metallopanstimulin 1, MPS-1, ribosomal protein S27, S27 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rps27 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of ribosome
- Ribosomal protein S27
- protein binding
Pathways
Biological processes and signaling networks where the Rps27 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- Alzheimer disease
- Diamond-Blackfan anemia type 17
- chronic periodontal disease
regulates
- TP53
- RNR
- BLM
role in cell
- apoptosis
- cell death
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- pre-ribosome
- presynaptic regions
- postsynaptic region
- ribosome
- Nucleus
- Mitochondria
- cytosol
- nucleoplasm
- synapse
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rps27 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic translation
- ribosomal small subunit biogenesis
- rRNA processing
- ribosomal small subunit assembly
- translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- postsynaptic density
- small-subunit processome
- cytosolic ribosome
- cytosolic small ribosomal subunit
- cytosol
- nucleolus
- ribosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- RNA binding
- protein binding
- structural constituent of ribosome