Vgll3 Gene Summary [Mouse]
Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system; heart; nervous system; skeletal musculature; and trunk mesenchyme. Orthologous to human VGLL3 (vestigial like family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vgll3 |
| Official Name | vestigial like family member 3 [Source:MGI Symbol;Acc:MGI:1920819] |
| Ensembl ID | ENSMUSG00000091243 |
| Bio databases IDs | |
| Aliases | vestigial like family member 3 |
| Synonyms | 1700110N18Rik, 4832416J22, FLJ38507, RGD1560030, vestigial-like family member 3, VGL-3, Vito-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vgll3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Short repeats in human TONDU, fly vestigial and other proteins
- Vestigial/Tondu family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiac fibrosis
- epithelial cancer
- prostate cancer
- chronic obstructive pulmonary disease
- prostatic carcinoma
- breast carcinoma
- diabetic ketoacidosis
role in cell
- proliferation
- expression in
- phosphorylation in
- differentiation
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vgll3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus